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KMID : 0363220120500121073
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Korean Journal of Dermatology
2012 Volume.50 No. 12 p.1073 ~ p.1076
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Jin Sang-Yun
Kim Do-Hun
Choi Yun-Seok
Kwon Jae-Hyun
Lee Ai-Young
Lee Seung-Ho
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Abstract
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Most cases of delayed skin reactions attributed to non-ionic iodinated contrast media, reported to date, have been maculopapular rash, which frequently occurs on the trunk and proximal region of the extremities. Only few cases of fixed drug eruption caused by non-ionic iodinated contrast media have been reported. A 48-year-old man developed multiple sharply marginated, hyperpigmented, oval patches on the trunk and extremities after receiving iodixanol (Visipaque(R), GE healthcare, USA). The patch test was carried out with a panel of the available iodinated non-ionic contrast media, but did not induce a positive reaction to any of the tested contrast media. The provocation test was carried out with iodixanol as 1/10 of the amount administered during the procedure that caused the reaction. On the following morning, the lesions increased in size and number. We report a case of iodixanol-induced fixed drug eruption, diagnosed by a systemic provocation test.
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KEYWORD
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Contrast media, Delayed reactions, Fixed drug eruption, Iodixanol, Systemic provocation test
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